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KMID : 0359920090280010041
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Korean Journal of Nephrology
2009 Volume.28 No. 1 p.41 ~ p.43
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A Case of Lactic Acidosis Associated with Prolonged Linezolid Therapy
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Chung Seung-Kyu
Jeon Jin-Seok
Noh Hyun-Jin
Han Dong-Cheol
Kim Cheol
Kwon Soon-Hyo
Kim Tae-Hyong
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Abstract
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Lactic acidosis is the most common cause of metabolic acidosis in hospitalized patients. Although impaired tissue oxygenation is usually responsible for the rise in lactate production, lactic acidosis could be caused by drugs including metformin and the nucleoside reverse-transcriptase inhibitors. Linezolid, an oxazolidinone antibiotic, is currently indicated to treat serious infections caused by vancomycin-resistant enterococcus and other gram-positive organisms. A 74-year old woman was found to have pyogenic vertebral osteomyelitis and treated with linezolid. Thirty-one days after linezolid therapy, she developed severe lactic acidosis. We report a case of lactic acidosis associated with prolonged linezolid therapy.
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KEYWORD
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Linezolid, Lactic acidosis
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